Predavanje z naslovom Molekularna sistemska biologija priono

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Predavanje z naslovom Molekularna sistemska biologija priono

Odgovor Napisal/-a saso » 16.9.2008 16:51

Vabilo na predavanje na Kemijskem inštitutu v petek, 19. septembra 2008 ob 14h v veliki predavalnici Kemijskega inštituta na Hajdrihovi 19

Prionske bolezni spadajo med ene najbolj enigmatičnih pojavov v biologiji, saj prioni za podvojevanje ne potrebujejo nukleinskih kislin. Za odkritje in odstiranje skrivnosti prionov so bile doslej podeljene že tri Nobelove nagrade.
Vabimo vas na predavanje prof. Adriana Aguzzija, iz Inštituta za nevropatologijo Univerzitetne bolnice v Zürichu iz Švice, enega od vodilnih strokovnjakov na področju raziskav prionov.
Predavanje z naslovom Molekularna sistemska biologija prionov bo v petek, 19. septembra ob 14h v veliki predavalnici Kemijskega inštituta na Hajdrihovi 19 v Ljubljani.


Molecular systems biology of prions
Prof. dr. Adriano Aguzzi
Institute of Neuropathology, University Hospital of Zürich, Zürich, Switzerland
Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases of humans and many animal species caused by prions. The main constituent of prions is PrPSc, an aggregated moiety of the host-derived membrane glycolipoprotein PrPC. Prions were found to encipher many phenotypic, genetically stable TSE variants. The latter is very surprising, since PrPC is encoded by the host genome and all prion strains share the same amino acid sequence. Here I will review what is known about the infectivity, the neurotoxicity, and the neuroinvasiveness of prions. Also, I will explain why I regard the prion strain question as a fascinating challenge – with implications that go well beyond prion science. Finally, I will report some recent results obtained in my laboratory, which is attempting to address the strain question and some other basic issues of prion biology with a “systems” approach that utilizes organic chemistry, photophysics, proteomics, and mouse transgenesis.
Vabljeni !

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